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8-(6-bromo-benzo[1,3]dioxol-5-ylsulfanyl)-9-(3-isopropylamino-propyl)-adenine
- Development stage
- Unknown
- Modality
- Small Molecules
01
Overview
This compound is a synthetic small molecule belonging to the diarylthioethers class and is an adenine derivative. It was developed as an experimental inhibitor of heat shock protein HSP90 (including HSP90-alpha and its yeast homolog HSP82). The molecule binds to the ATP-binding site of HSP90, inhibiting its chaperone function. This mechanism disrupts the folding and stability of client proteins involved in cell growth and survival pathways—making it a potential candidate for anticancer drug development. However, there are no known clinical trials or approved indications for this compound as of now[1][2][4][5].
- Other names
- 8-[(6-bromo-2H-1,3-benzodioxol-5-yl)sulfanyl]-9-[3-(isopropylamino)propyl]-9H-purin-6-amine8-(6-Bromobenzo[d][1,3]dioxol-5-ylthio)-9-(3-(isopropylamino)propyl)-9H-purin-6-amina
02
Targets
HSP90AA1 (Heat shock protein HSP90-alpha)HSP90 (Heat shock protein 90 chaperone complex)
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